Everything about ceesdekker.net
Everything about ceesdekker.net
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‘The next is nanopores, which can be our oldest line of investigation and which has now resulted in DNA sequencers depending on nanopores. We pull personal DNA strands through a nanopore and can then read from the nucleotide sequence. Pretty lately, we even managed to read out only one protein for The 1st time working with This method. But this line of analysis is not just about developing applications, and also about true biological questions.
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
Multicolor imaging with the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and to start with ever study on the dynamics DNA supercoils and the discovery of supercoil hopping
Case in point (3) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim of your pore is highlighted in purple, along with a 3D rendering of your motion of the DNA rod is exhibited.
Several relevant developments followed, the place our group proven diverse transistor variants for example solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into modest evidence-of-theory electronic circuits.
2011, 1st in vitro measurements of transport across a single biomimetic nuclear pore elaborate; enhancement of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
‘You should not just think of the inquiries of tomorrow, and also look at the issues on the day right after tomorrow’
At the moment, we also realized that it should be possible to use only one semiconducting carbon nanotube to help make a transistor — and we established out to make it. We stretched personal semiconducting nanotubes across metallic electrodes and used the fundamental silicon substrate being a gate electrode, setting up the basic a few-terminal structure of a discipline-impact transistor (Fig.
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
‘That problems the artificial cell, as Component of the Dutch BaSyC initiative. Craig Venter looked best-down in those days and determined about 5 hundred genes which can be minimally expected for a working mobile. We wish to appear bottom-up: how can we shift from the couple of molecules to a ceesdekker.net whole Organic system?
2005, discovery of the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of lengthy-vary conformational variations in Mre11/DNA repair service complexes; and to start with power measurements with a DNA molecule in the nanopore
It absolutely was a very interesting time, in the course of which I gained loads of aid from Delft College of Engineering, wherever I had been a professor at the time, and I begun a number of collaborations with molecular biologists. That assisted me discover a good deal.’